Martin Hulce, PhD

Professor, Organic Chemistry

Dr. Martin Hulce
(402) 280-2271
mhulce@creighton.edu
Dr. Hulce's website

B.S., Butler Univ. - 1978
M.A., Johns Hopkins Univ. - 1980
Ph.D., Johns Hopkins Univ. - 1983

Dr. Hulce leads the Department of Chemistry's Laboratory for Metalloorganic Chemistry.

Dr. Hulce's laboratory investigates new synthetic methods in organic chemistry and the preparation of small, functionally rich organic molecules.  Ongoing work includes the development of new allene-forming reactions, the synthesis of modified amino acids for solid phase peptide synthesis, the generation, use and detection of singlet oxygen, and halogen-specific aromatic dehalogenation reactions.

 

 

Selected recent publications:

1. Carney, J. M.; Hammer, R. J.; Hulce, M.; Lomas, C. M.; Miyashiro, D. "High-Efficiency Microphotooxidation Using Milliwatt Light-emitting Diode Sources," Tetrahedron Letters 2011, 52, 352-355. DOI:10.1016/j.tetlet.2010.11.071

2. Smith, D.D.; Mao, M.; Young, H.; Hulce, M. "Synthesis of 4-Arylmethyl-L-hisitidine analogues for Structure-Activity Studies of Position 10 of CGRP," Advances in Experimental Medicine & Biology 2009, 611, 131-132.

3. Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D. "N-Terminal bis(2-Chloroethyl)amino and Fluorosulfonyl Analogues of Calcitonin Gene-Related Peptide(8-37): Irreversible Antagonists at Calcitonin Gene-Related Peptide Receptors," Chemical Biology and Drug Design 2007, 70, 216-226.

4.  Taylor, C.K.; Smith, D.D.; Hulce, M.; Abel, P.W. "Pharmacological Characterization of Novel High Affinity CGRP Receptor Antagonists that are Selective for Human CGRP Receptors," Journal of Pharmacology and Experimental Therapeutics 2006, 319, 749-757.

5.  Mattson, B.; Hulce, M; Cheng, W.; Greimann, J.; Hoette, T; Menzel, P. "Propanol to Propane. An Advanced Laboratory Experiment Using Two Gas-phase Heterogeneous Catalysts," Journal of Chemical Education 2006, 83, 421-424.

6. Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D., "Solvent Effects on Coupling Yields During Rapid Solid Phase Synthesis of CGRP(8-37) Employing in situ Neutralization", Journal of Peptide Science 2005, 65, 84-89.

7. Reidelberger, R.D.; Hernandez, J.; Fritzsch, B.; Huce, M. "Abdominal Vagal Mediation of the Satiety Effects of CCK in Rats," American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2004, 286, R1005-R1012.

8. Reidelberger, R.D.; Castellanos, D.; Hulce, M. "Effects of Peripheral CCK Receptor Blockade on Food Intake in Rats," American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2003, 285, R429-R437.

9. Smith, D.D.; Saha, S.; Fang, G.; Schaffert, C.; Waugh, D.J.J.; Zeng, W.; Toth, G.; Hulce, M.; Abel, P.W. "Modifications to the N-terminus but not the C-terminus of Calcitonin gene-Related Peptide(8-37) Produces Antagonists with Increased Affinity for CGRP Receptors," Journal of Medicinal Chemistry 2003, 46, 2427-2435.

10. Reidelberger, R.D.; Heimann, D.; Kelsey, L.; Hulce, M. "Effects of Peripheral CCK Receptor Blockade on Feeding Responses to Duodenal Nutrient Infusions in Rats," American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2003, 284, R389-R398.

11. Reidelberger, R.D.; Kelsey, L.; Heimann, D.; Hulce, M. "Effects of Peripheral CCK Blockade on Gastric Emptying in Rats," American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2003, 284, R66-R75.

12. Smith, D.D.; Hulce, M.; Waugh, D.J.J.; Abel, P.W. "Structural Characterization of Dibenzylated-CGRP(8-37), a Byproduct from the N- -Benzylation of CGRP(8-37)," in Peptides: The Wave of the Future, Houghten, R.A.; Lebl, M., eds; Kluwer Academic Publishers: Dordrecht, 2002, 250-251.

13. Trætteberg, M.; Khaikin, L.S.; O.E. Grikina, O.E.; Liebman, J.F.; Hulce, M. "Structure, Spectra, and Intramolecular Motions of 1,4-Bis(trimethylsilyl)-1,3-butadiyne: an Electron Diffraction Study Using the Results of Spectral Analysis Based on Scaled Quantum-Chemical Force Field for Calculating Vibrational Effects", Journal of Molecular Structure 2001, 559, 295-313.

14. Hulce, M.; Marks, D.W. "Organic Solvent-Free Phase-Transfer Oxidation of Alcohols Using Hydrogen Peroxide", Journal of Chemical Education 2001, 78, 66-68.