Martin Hulce, PhD

Professor, Organic Chemistry

Dr. Martin Hulce
(402) 280-2271
mhulce@creighton.edu
Dr. Hulce's website

B.S., Butler Univ. - 1978
M.A., Johns Hopkins Univ. - 1980
Ph.D., Johns Hopkins Univ. - 1983

Dr. Hulce leads the Department of Chemistry's Laboratory for
Metalloorganic Chemistry.

Dr. Hulce's laboratory investigates new synthetic methods in organic
chemistry and the preparation of small, functionally rich organic
molecules. Ongoing work includes the development of new allene-forming
reactions, the synthesis of modified amino acids for solid phase peptide
synthesis, the generation, use and detection of singlet oxygen, and
halogen-specific aromatic dehalogenation reactions.





Selected recent publications:

1. Carney, J. M.; Hammer, R. J.; Hulce, M.; Lomas, C. M.; Miyashiro, D.
"High-Efficiency Microphotooxidation Using Milliwatt Light-emitting Diode
Sources," Tetrahedron Letters 2011, 52, 352-355.
DOI:10.1016/j.tetlet.2010.11.071

2. Smith, D.D.; Mao, M.; Young, H.; Hulce, M. "Synthesis of
4-Arylmethyl-L-hisitidine analogues for Structure-Activity Studies of
Position 10 of CGRP," Advances in Experimental Medicine & Biology 2009,
611, 131-132.

3. Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D. "N-Terminal
bis(2-Chloroethyl)amino and Fluorosulfonyl Analogues of Calcitonin
Gene-Related Peptide(8-37): Irreversible Antagonists at Calcitonin
Gene-Related Peptide Receptors," Chemical Biology and Drug Design 2007,
70, 216-226.

4. Taylor, C.K.; Smith, D.D.; Hulce, M.; Abel, P.W. "Pharmacological
Characterization of Novel High Affinity CGRP Receptor Antagonists that are
Selective for Human CGRP Receptors," Journal of Pharmacology and
Experimental Therapeutics 2006, 319, 749-757.

5. Mattson, B.; Hulce, M; Cheng, W.; Greimann, J.; Hoette, T; Menzel, P.
"Propanol to Propane. An Advanced Laboratory Experiment Using Two
Gas-phase Heterogeneous Catalysts," Journal of Chemical Education 2006,
83, 421-424.

6. Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D., "Solvent Effects on
Coupling Yields During Rapid Solid Phase Synthesis of CGRP(8-37) Employing
in situ Neutralization", Journal of Peptide Science 2005, 65, 84-89.

7. Reidelberger, R.D.; Hernandez, J.; Fritzsch, B.; Huce, M. "Abdominal
Vagal Mediation of the Satiety Effects of CCK in Rats," American Journal
of Physiology - Regulatory, Integrative and Comparative Physiology 2004,
286, R1005-R1012.

8. Reidelberger, R.D.; Castellanos, D.; Hulce, M. "Effects of Peripheral
CCK Receptor Blockade on Food Intake in Rats," American Journal of
Physiology - Regulatory, Integrative and Comparative Physiology 2003, 285,
R429-R437.

9. Smith, D.D.; Saha, S.; Fang, G.; Schaffert, C.; Waugh, D.J.J.; Zeng,
W.; Toth, G.; Hulce, M.; Abel, P.W. "Modifications to the N-terminus but
not the C-terminus of Calcitonin gene-Related Peptide(8-37) Produces
Antagonists with Increased Affinity for CGRP Receptors," Journal of
Medicinal Chemistry 2003, 46, 2427-2435.

10. Reidelberger, R.D.; Heimann, D.; Kelsey, L.; Hulce, M. "Effects of
Peripheral CCK Receptor Blockade on Feeding Responses to Duodenal Nutrient
Infusions in Rats," American Journal of Physiology - Regulatory,
Integrative and Comparative Physiology 2003, 284, R389-R398.

11. Reidelberger, R.D.; Kelsey, L.; Heimann, D.; Hulce, M. "Effects of
Peripheral CCK Blockade on Gastric Emptying in Rats," American Journal of
Physiology - Regulatory, Integrative and Comparative Physiology 2003, 284,
R66-R75.

12. Smith, D.D.; Hulce, M.; Waugh, D.J.J.; Abel, P.W. "Structural
Characterization of Dibenzylated-CGRP(8-37), a Byproduct from the N-
-Benzylation of CGRP(8-37)," in Peptides: The Wave of the Future,
Houghten, R.A.; Lebl, M., eds; Kluwer Academic Publishers: Dordrecht,
2002, 250-251.

13. Traetteberg, M.; Khaikin, L.S.; O.E. Grikina, O.E.; Liebman, J.F.;
Hulce, M. "Structure, Spectra, and Intramolecular Motions of
1,4-Bis(trimethylsilyl)-1,3-butadiyne: an Electron Diffraction Study Using
he Results of Spectral Analysis Based on Scaled Quantum-Chemical Force
Field for Calculating Vibrational Effects", Journal of Molecular Structure
2001, 559, 295-313.

14. Hulce, M.; Marks, D.W. "Organic Solvent-Free Phase-Transfer Oxidation
of Alcohols Using Hydrogen Peroxide", Journal of Chemical Education 2001,
78, 66-68.