Martin Hulce, PhD

Professor, Organic Chemistry

Dr. Martin Hulce
(402) 280-2271
mhulce@creighton.edu
Dr. Hulce's website

B.S., Butler Univ. - 1978
M.A., Johns Hopkins Univ. - 1980
Ph.D., Johns Hopkins Univ. - 1983

Dr. Hulce leads the Department of Chemistry's Laboratory for Metalloorganic Chemistry.

Dr. Hulce's laboratory investigates new methods of preparing carbon-carbon bonds by exploiting modern metalloorganic chemistry. Ongoing applications of their carbon-carbon bond-forming strategies include the synthesis of model molecules to study DNA site-specific anticancer antibiotics, novel allene-forming reactions, and the preparation of molecules that mimic peptides.

 

 

Selected recent publications:

1. Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D. "N-Terminal bis(2-Chloroethyl)amino and Fluorosulfonyl Analogues of Calcitonin Gene-Related Peptide(8-37): Irreversible Antagonists at Calcitonin Gene-Related Peptide Receptors," Chemical Biology and Drug Design 2007, 70, 216-226.

2.  Taylor, C.K.; Smith, D.D.; Hulce, M.; Abel, P.W. "Pharmacological Characterization of Novel High Affinity CGRP Receptor Antagonists that are Selective for Human CGRP Receptors," Journal of Pharmacology and Experimental Therapeutics 2006, 319, 749-757.

3.  Mattson, B.; Hulce, M; Cheng, W.; Greimann, J.; Hoette, T; Menzel, P. "Propanol to Propane. An Advanced Laboratory Experiment Using Two Gas-phase Heterogeneous Catalysts," Journal of Chemical Education 2006, 83, 421-424.

4. Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D., "Solvent Effects on Coupling Yields During Rapid Solid Phase Synthesis of CGRP(8-37) Employing in situ Neutralization", Journal of Peptide Science 2005, 65, 84-89.

5. Reidelberger, R.D.; Hernandez, J.; Fritzsch, B.; Huce, M. "Abdominal Vagal Mediation of the Satiety Effects of CCK in Rats," American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2004, 286, R1005-R1012.

6. Reidelberger, R.D.; Castellanos, D.; Hulce, M. "Effects of Peripheral CCK Receptor Blockade on Food Intake in Rats," American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2003, 285, R429-R437.

7. Smith, D.D.; Saha, S.; Fang, G.; Schaffert, C.; Waugh, D.J.J.; Zeng, W.; Toth, G.; Hulce, M.; Abel, P.W. "Modifications to the N-terminus but not the C-terminus of Calcitonin gene-Related Peptide(8-37) Produces Antagonists with Increased Affinity for CGRP Receptors," Journal of Medicinal Chemistry 2003, 46, 2427-2435.

8. Reidelberger, R.D.; Heimann, D.; Kelsey, L.; Hulce, M. "Effects of Peripheral CCK Receptor Blockade on Feeding Responses to Duodenal Nutrient Infusions in Rats," American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2003, 284, R389-R398.

9. Reidelberger, R.D.; Kelsey, L.; Heimann, D.; Hulce, M. "Effects of Peripheral CCK Blockade on Gastric Emptying in Rats," American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2003, 284, R66-R75.

10. Smith, D.D.; Hulce, M.; Waugh, D.J.J.; Abel, P.W. "Structural Characterization of Dibenzylated-CGRP(8-37), a Byproduct from the N- -Benzylation of CGRP(8-37)," in Peptides: The Wave of the Future, Houghten, R.A.; Lebl, M., eds; Kluwer Academic Publishers: Dordrecht, 2002, 250-251.

11. Trætteberg, M.; Khaikin, L.S.; O.E. Grikina, O.E.; Liebman, J.F.; Hulce, M. "Structure, Spectra, and Intramolecular Motions of 1,4-Bis(trimethylsilyl)-1,3-butadiyne: an Electron Diffraction Study Using the Results of Spectral Analysis Based on Scaled Quantum-Chemical Force Field for Calculating Vibrational Effects", Journal of Molecular Structure 2001, 559, 295-313.

12. Hulce, M.; Marks, D.W. "Organic Solvent-Free Phase-Transfer Oxidation of Alcohols Using Hydrogen Peroxide", Journal of Chemical Education 2001, 78, 66-68.

13. Malone, J.A.; Reidelberger, R.D.; Hulce, M. "Synthesis of a Radiolabelled type A Cholecystokinin Receptor Antagonist, (R)-N-pentyl-N-(4,5-di[3H]pentyl) N"-(3-quinolinoyl)glutamic acid amide", Journal of Labelled Compounds and Radiopharmaceuticals 2000, 43, 77-90.