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James Fletcher, PhD Assistant Professor |
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Research in the Fletcher lab involves the design, synthesis and characterization of interesting organic and organometallic molecules. Projects include: (1) the development of peptidomimetic architectures (organic non-peptides shaped like peptides) with the purpose of creating new biomaterials (2) the synthesis of organic chelators and their organometallic complexes with the purpose of creating new chemosensors and photosensitizing dyes for solar cell applications (3) the attachment of peptides with organometallic units for the purposes of creating new biochemical probes and imaging agents
Selected recent publications: |
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James
Fletcher
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Fletcher, J.T.; Finlay, J.A.; Callow, M.E.; Callow, J.A.; Ghadiri, M.R. “A combinatorial approach to the discovery of biocidal six-residue cyclic D,L-alpha-peptides against the bacteria methicillin-resistant Staphylococcus aureus (MRSA) and E-coli and the biofouling algae Ulva linza and Navicula perminuta” Chem. Eur. J.2007, 13, 4008-4013. Fletcher, J.T.; Therien, M.J.“Extreme Electronic Modulation of the Cofacial Porphyrin Structural Motif” J. Am. Chem. Soc. 2002, 124(16), 4298-4311. Fletcher, J.T.; Therien, M.J. “Strongly Coupled Porphyrin Arrays Featuring Both ¹-Cofacial and Linear-¹-Conjugative Interactions” Inorg. Chem.2002, 41(2), 331-341. Fletcher, J.T.; Therien, M.J.“Transition-Metal-Mediated [2 + 2 + 2] Cycloaddition Reactions with Ethyne-Containing Porphyrin Templates: New Routes to Cofacial Porphyrin Structures and Facially-Functionalized (Porphinato)metal Species” J. Am. Chem. Soc. 2000, 122(49), 12393-12394. Moore, K.T.; Fletcher, J.T.; Therien, M.J. “Synthesis, NMR and EPR Spectroscopy, Electrochemical Properties, and Structural Studies of [5,10,15,20-Tetrakis(perfluoroalkyl)porphinato]iron(II) and -iron(III) Complexes” J. Am. Chem. Soc. 1999, 121(22), 5196-5209.
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